Related Experiment Video
Updated: Mar 25, 2026
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
Published on: June 15, 2020
Correlations Between Echocardiographic Systolic and Diastolic Function with Cardiac Catheterization in Biventricular
H Nadorlik1, C Stiver2, S Khan2
1Heart Center, Nationwide Children's Hospital, Columbus, OH, USA. holly.nadorlik@nationwidechildrens.org.
Insights
Echocardiographic measurements for left ventricular (LV) systolic function did not correlate with catheterization data in pediatric congenital heart patients. However, strain rate analysis showed significant correlation with LV end-diastolic pressure, suggesting its potential for diastolic function assessment.
Area of Science:
- Pediatric Cardiology
- Echocardiography
- Cardiac Catheterization
Background:
- Advanced echocardiographic techniques offer potential for precise left ventricular (LV) function assessment.
- While adult studies validate echocardiographic-invasive data correlations, such data is scarce in pediatric congenital heart disease (CHD).
Purpose of the Study:
- To determine which echocardiographic measurements best correlate with LV systolic and diastolic parameters obtained via cardiac catheterization in pediatric CHD patients.
- To evaluate the utility of newer echocardiographic parameters, including strain rate analysis, in this specific population.
Main Methods:
- Simultaneous echocardiography and cardiac catheterization were performed in pediatric patients with two-ventricle physiology.
- Echocardiographic parameters included ejection fraction, displacement, tissue Doppler imaging (TDI) s' and e' waves, global longitudinal strain, and strain rate (SR) s' and e' waves.
- Catheterization data utilized dP/dt for systolic function and LV end-diastolic pressure (LVEDP) for diastolic function; Pearson correlation was employed.
Main Results:
- No significant correlations were found between catheterization dP/dt and any of the assessed LV systolic echocardiographic parameters.
- LVEDP demonstrated significant correlations with strain rate e' (SRe') (r = -0.4, p = 0.03), strain rate a' (SRa') (r = -0.4, p = 0.03), and the E/SRe' ratio (r = 0.5, p = 0.004).
- These findings indicate a disconnect between echocardiographic systolic markers and invasive measures in this cohort.
Conclusions:
- Current echocardiographic measures of LV systolic function do not reliably correlate with invasive catheterization data in pediatric CHD patients.
- Strain rate analysis shows promise as a viable method for estimating LVEDP, offering a potential non-invasive tool for diastolic function assessment in this population.
- Further research is warranted to identify optimal echocardiographic parameters for assessing LV systolic function in pediatric CHD.
Abstract:
Newer echocardiographic techniques may allow for more accurate assessment of left ventricular (LV) function. Adult studies have correlated these echocardiographic measurements with invasive data, but minimal data exist in the pediatric congenital heart population. Purpose of this study was to evaluate which echocardiographic measurements correlated best with LV systolic and diastolic catheterization parameters. Patients with two-ventricle physiology who underwent simultaneous echocardiogram and cardiac catheterization were included. Images were obtained in the four-chamber view. LV systolic echocardiographic data included ejection fraction, displacement, tissue Doppler imaging (TDI) s' wave, global longitudinal strain, and strain rate (SR) s' wave. Diastolic echocardiographic data included mitral E and A waves, TDI e' and a' waves, and SRe' and SRa' waves. E/TDI e', TDI e'/TDI a', E/SRe', and SRe'/SRa' ratios were also calculated. Catheterization dP/dt was used as a marker for systolic function, and LV end-diastolic pressure (EDP) was used as a marker for diastolic function. Correlations of the echocardiographic and catheterization values were performed using Pearson correlation. Twenty-nine patients were included (14 females, 15 males). Median age at catheterization was 3.4 years (0.04-17.4 years). dP/dt was 1258 ± 353 mmHg/s, and LVEDP was 10.8 ± 2.4 mmHg. There were no significant correlations between catheterization dP/dt and systolic echocardiographic parameters. LVEDP correlated significantly with SRe' (r = -0.4, p = 0.03), SRa' (r = -0.4, p = 0.03), and E/SRe' (r = 0.5, p = 0.004). In pediatric congenital heart patients, catheterization dP/dt did not correlate with echocardiographic measurements of LV systolic function. Further studies are needed to determine which echocardiographic parameter best describes LV systolic function in this population. Strain rate analysis significantly correlated with LVEDP. Strain rate analysis should be considered as an alternative method to estimate LVEDP in this patient population.
Related Concept Videos
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
01:17Imaging Studies for Cardiovascular System I:Echocardiography
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:23Mitral Stenosis II: Clinical features and Diagnostic Tests
01:30Acute Coronary Syndrome III: Diagnostic Studies