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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Related Experiment Video

Updated: Mar 25, 2026

Osteoclast Derivation from Mouse Bone Marrow
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The "love-hate" relationship between osteoclasts and bone matrix.

Nadia Rucci1, Anna Teti1

  • 1Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.

Matrix Biology : Journal of the International Society for Matrix Biology
|February 28, 2016
PubMed
Summary

Osteoclasts and bone matrix have a complex relationship crucial for skeletal health. Understanding their interaction can lead to treatments for bone diseases.

Keywords:
Bone matrixBone resorptionIntegrinOsteoclast

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Area of Science:

  • Skeletal Biology
  • Cell Biology
  • Biochemistry

Background:

  • Osteoclasts are specialized cells responsible for bone resorption.
  • A dynamic interplay exists between osteoclasts and the bone matrix, essential for maintaining skeletal integrity.
  • Dysregulation of this interaction contributes to bone diseases characterized by altered bone mass and quality.

Purpose of the Study:

  • To explore the intricate physical, molecular, and regulatory connections between osteoclasts and the mineralized bone matrix.
  • To elucidate the mechanisms governing osteoclast-matrix interactions and their role in bone homeostasis.
  • To discuss pathological alterations in these interactions and potential therapeutic targets for bone diseases.

Main Methods:

  • Review of existing literature on osteoclast biology and bone matrix.
  • Analysis of studies detailing the physical and molecular interactions between osteoclasts and bone matrix components.
  • Examination of regulatory feedback loops and their disruption in bone pathologies.

Main Results:

  • Osteoclast activity is stimulated by matrix contact but also counteracted by released matrix components.
  • This interaction is vital for controlled bone resorption, bone tissue integrity, and skeletal health.
  • Released matrix factors influence local bone cell regulation and systemic homeostasis.

Conclusions:

  • The balance of osteoclast-matrix interaction is critical for skeletal health.
  • Understanding these relationships offers potential therapeutic strategies for bone diseases.
  • Targeting osteoclast-to-matrix interactions may improve human bone health and combat pathologies.