Related Experiment Video

Updated: Mar 25, 2026

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
07:01

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

2.0K

Targeting non-coding RNA for the therapy of renal disease

Laura Denby1, Andrew H Baker1

  • 1Centre for Cardiovascular Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, UK.

Current Opinion in Pharmacology
|February 28, 2016
PubMed

Insights

MicroRNAs regulate gene expression and are involved in kidney diseases like diabetes and fibrosis. Targeting specific microRNAs offers promising therapeutic strategies for renal conditions.

Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • miRNAs function by binding to mRNA targets, influencing protein production.
  • They are implicated in the pathophysiology of various kidney diseases.

Purpose of the Study:

  • To review the current understanding of miRNA roles in renal diseases.
  • To explore potential miRNA biomarkers for kidney conditions.
  • To identify promising miRNA targets for therapeutic intervention.

Main Methods:

  • Literature review of studies on miRNAs in kidney diseases.
  • Analysis of miRNA involvement in diabetes, renal fibrosis, and IgA nephropathy.
  • Evaluation of miRNA targets for clinical translation.

Main Results:

  • miRNAs play a significant role in the onset and progression of kidney diseases.
  • Specific miRNAs are associated with tubulointerstitial and glomerulosclerosis.
  • Multiple mRNA targets of a single miRNA suggest significant therapeutic potential.

Conclusions:

  • miRNAs are key players in renal pathophysiology.
  • Targeting miRNAs presents a novel therapeutic avenue for kidney diseases.
  • Further research into miRNA targets could lead to effective clinical treatments.

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.3K
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy12:03

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy

Published on: September 5, 2016

8.3K

Related Concept Videos

Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.2K
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.6K
RNA Interference01:23

RNA Interference

7.8K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
19.0K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.8K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
16.2K