Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

950
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
950
Renal Corpuscle01:20

Renal Corpuscle

8.5K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
8.5K
Nephrons01:10

Nephrons

8.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.4K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.8K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.8K
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

1.4K
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
1.4K
Glomerular Filtration01:15

Glomerular Filtration

6.9K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology." Kidney International, 2023;104:36-45.

Kidney international·2023
Same author

[IgA nephropathy].

Innere Medizin (Heidelberg, Germany)·2023
Same author

Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2023
Same author

Use of Analog and Human Insulin in a European Hemodialysis Cohort With Type 2 Diabetes: Associations With Mortality, Hospitalization, MACE, and Hypoglycemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2023
Same author

Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial.

Lancet (London, England)·2023
Same author

Sodium-glucose cotransporter 2 inhibition in primary and secondary glomerulonephritis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2023

Related Experiment Video

Updated: Mar 25, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.7K

Primary glomerulonephritides.

Jürgen Floege1, Kerstin Amann2

  • 1Department of Nephrology and Clinical Immunology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany.

Lancet (London, England)
|February 29, 2016
PubMed
Summary
This summary is machine-generated.

Glomerulonephritis, a group of rare kidney diseases, often affects young adults and can lead to kidney failure. This review focuses on IgA nephropathy and other common types, summarizing recent findings on their causes, prognosis, and treatment.

More Related Videos

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

10.1K
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

6.2K

Related Experiment Videos

Last Updated: Mar 25, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.7K
Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
09:12

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

10.1K
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

6.2K

Area of Science:

  • Nephrology
  • Rare Diseases
  • Immunology

Background:

  • Glomerulonephritides are rare but significant kidney diseases, frequently impacting young individuals.
  • These conditions can lead to chronic kidney disease and end-stage renal failure, incurring substantial morbidity and healthcare costs.
  • IgA nephropathy is a leading cause of end-stage renal disease in young adults.

Purpose of the Study:

  • To summarize current knowledge on the clinical presentation, pathogenesis, prognosis, and treatment of glomerulonephritides.
  • To focus on data published between 2008 and 2015.
  • To highlight common European glomerulonephritis types and rare complement-associated forms.

Main Methods:

  • Literature review of scientific data published between 2008 and 2015.
  • Synthesis of information on clinical signs, pathogenesis, prognosis, and treatment.
  • Focus on specific glomerulonephritis types including IgA nephropathy, membranous glomerulonephritis, minimal change disease, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, dense deposit disease, and C3 glomerulonephritis.

Main Results:

  • Glomerulonephritides, despite rarity, have a significant impact, particularly on young populations.
  • IgA nephropathy is identified as the most common cause of end-stage renal disease in young adults.
  • The review covers a spectrum of glomerulonephritis types, from common to rare complement-mediated conditions.

Conclusions:

  • Understanding the clinical aspects, underlying mechanisms, and treatment options for glomerulonephritis is crucial.
  • Recent research provides valuable insights into managing these kidney diseases.
  • Effective management strategies are needed to mitigate the progression to chronic kidney disease and end-stage renal failure.