[ROC curve-based evaluation of platelet parameters for predicting delayed renal graft function]

Area of Science:

• Nephrology
• Transplantation Immunology
• Hematology

Background:

• Delayed graft function (DGF) is a common complication following kidney transplantation.
• Early identification of DGF is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

• To evaluate the predictive value of five platelet parameters for DGF in renal transplant recipients.
• To determine if specific platelet parameter variations correlate with the development of DGF.

Main Methods:

• Retrospective analysis of 330 renal transplant recipients' pre- and postoperative data.
• Assessment of platelet count (PLT), P-LCR, MPV, PDW, and PCT in relation to DGF occurrence.

Main Results:

• Postoperative platelet parameters showed significant differences between DGF and non-DGF groups.
• MPV, PDW, and P-LCR demonstrated predictive value for DGF, with MPV showing the highest diagnostic accuracy (AUC=0.762).
• PLT and PCT lacked significant predictive value for DGF.

Conclusions:

• Postoperative variations in MPV, PDW, and P-LCR are associated with DGF in kidney transplant patients.
• Monitoring MPV, particularly levels >11.55 fl, can assist in the early diagnosis and management of DGF.