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Ionic versus nonionic contrast media: safety, tolerance, and rationale for use
1Mallinckrodt Institute of Radiology, Washington School of Medicine, St. Louis, Missouri 63110.
Urologic Radiology
|January 1, 1989
Summary
Low osmolar contrast media, including ionic and nonionic types, show improved patient safety and tolerance. Widely available agents like Iohexol, Iopamidol, Ioxaglate, and Ioversol are proven effective in clinical trials.
Area of Science:
- Radiology
- Medical Imaging
- Pharmacology
Background:
- Contrast media are essential for medical imaging procedures.
- Traditional high-osmolar contrast agents were associated with significant adverse events.
- Advancements have led to the development of low osmolar contrast media (LOCM).
Purpose of the Study:
- To review the clinical evidence supporting the safety and tolerability of LOCM.
- To highlight the availability of key LOCM agents in the United States.
Main Methods:
- Analysis of clinical experience and randomized controlled trials.
- Review of safety and patient tolerance data for LOCM.
Main Results:
- Numerous high-quality trials demonstrate improved patient tolerance and safety with LOCM.
- Both ionic and nonionic LOCM formulations are well-tolerated.
- Specific agents like Iohexol, Iopamidol, Ioxaglate, and Ioversol are now widely available.
Conclusions:
- Low osmolar contrast media represent a significant advancement in patient safety for diagnostic imaging.
- The established efficacy and safety profile of LOCM support their routine clinical use.