Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.7K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.7K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

2.7K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
2.7K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

12.9K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of physiological strain on lung epithelial cells by exposure to aerosolised quartz silica in a perfused bioreactor.

Frontiers in bioengineering and biotechnology·2026
Same author

Force Reveals Hidden Conformations and Dissociation Pathways in Individual π-Interacting Dimers.

Angewandte Chemie (International ed. in English)·2026
Same author

Bioinspired Strategies for Directional Water Transport in Asymmetric Membranes.

ACS applied polymer materials·2026
Same author

Advancing preclinical research with reconstructed in vitro skin models mimicking non-healing wounds.

International journal of pharmaceutics: X·2026
Same author

Exploring the Potential Role of Manganese-Based Zeolitic Imidazolate Framework Nanoparticles in Cancer Therapy: <i>In vitro</i> Studies Using Lung Cancer Cells.

International journal of nanomedicine·2026
Same author

Photoresponsive Metallo-Supramolecular Systems Constructed From a Bidentate Ligand.

Macromolecular rapid communications·2026

Related Experiment Video

Updated: Mar 25, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

21.4K

Articular cartilage: from formation to tissue engineering.

Sandra Camarero-Espinosa1, Barbara Rothen-Rutishauser, E Johan Foster

  • 1Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland. christoph.weder@unifr.ch.

Biomaterials Science
|March 1, 2016
PubMed
Summary

Cartilage tissue engineering aims to regenerate hyaline cartilage, a vital joint tissue that struggles to heal naturally. Current methods face challenges in replicating native tissue complexity and function.

More Related Videos

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
12:37

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

20.7K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Related Experiment Videos

Last Updated: Mar 25, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

21.4K
3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
12:37

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

20.7K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.7K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedics

Background:

  • Hyaline cartilage is crucial for synovial joint function, acting as a load-bearing and friction-reducing tissue.
  • Its avascular nature and low chondrocyte activity limit natural regeneration, leading to conditions like osteoarthritis.
  • Severe cartilage damage necessitates surgical intervention, highlighting the need for effective regenerative strategies.

Purpose of the Study:

  • To review the current advancements in cartilage tissue engineering.
  • To discuss biological aspects of hyaline cartilage formation, composition, and biomechanics.
  • To explore materials, scaffolds, fabrication methods, and cell-template interactions in cartilage regeneration.

Main Methods:

  • Literature review of current cartilage tissue engineering strategies.
  • Analysis of biological factors influencing hyaline cartilage regeneration.
  • Examination of materials science and fabrication techniques for engineered cartilage.

Main Results:

  • Despite significant research, replicating native cartilage's complex architecture and biomechanical properties remains challenging.
  • Few cartilage tissue engineering studies have progressed to clinical trials.
  • Key areas for development include biomaterials, scaffold design, fabrication methods, and cell-scaffold interactions.

Conclusions:

  • Cartilage tissue engineering faces hurdles in clinical translation due to the tissue's complexity.
  • Further research into biomaterials, scaffold design, and cell-template interactions is critical for successful regeneration.
  • Developing functional hyaline cartilage replacements requires a multidisciplinary approach integrating biology and engineering.