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Psoriasis in the third age.

M Gligora1, J Arzensek, D Rems

  • 1Dermatology Department, Hospital Maribor, Zagreb, Yugoslavia.

Acta Dermato-Venereologica. Supplementum
|January 1, 1989
PubMed
Summary
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This 10-year study tracked elderly psoriasis patients in Slovenia and Croatia. Etretinate treatment requires weekly monitoring of lipids and lipoproteins due to atherosclerosis risks in older adults.

Area of Science:

  • Dermatology
  • Geriatrics
  • Pharmacology

Background:

  • Elderly patients constitute a significant portion (12-25%) of hospital admissions.
  • Psoriasis prevalence among elderly inpatients varies regionally, reaching up to 6.1% in Zagreb.

Purpose of the Study:

  • To analyze the prevalence and characteristics of psoriasis in elderly patients over a decade.
  • To evaluate the impact of etretinate treatment on lipid profiles in older adults.

Main Methods:

  • Retrospective analysis of 241 elderly psoriasis patients (age >65) across Slovenian and Croatian centers over 10 years.
  • Monitoring of serum lipids, HDL, LDL cholesterol, and apolipoproteins weekly during etretinate therapy.

Main Results:

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  • Psoriasis vulgaris was most common (214 patients), with subtypes including arthropathic, pustular, and erythrodermic forms.
  • Etretinate treatment was associated with increased serum lipids and decreased HDL cholesterol.
  • Long-term etretinate use may elevate risks for atherosclerosis and coronary heart disease in the elderly.

    • Conclusions:

    • Psoriasis affects a notable percentage of elderly inpatients, with varied clinical presentations.
    • Close monitoring of lipid profiles is crucial for elderly patients on long-term etretinate to mitigate cardiovascular risks.