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Updated: Mar 25, 2026

Author Spotlight: Illuminating New Avenues for Adipose Tissue Metabolism and Disease Prevention
Published on: October 6, 2023
[Adiponectin receptor-targeted therapy for lifestyle-related diseases]
Masato Iwabu1, Toshimasa Yamauchi1, Miki Okada-Iwabu1
1Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan.
Abstract:
Given that appropriate control of responses of the body to nutritional status is assumed to modulate the pace of aging, thus prolonging lifespan and maintaining youth in humans, expectations are mounting worldwide for modalities targeting the pathways in metabolic regulation for healthy longevity. Of these, this review focuses attention on adiponectin-targeted therapy and discusses milestones in this approach, which include the discovery of the ability of adiponectin to protect against lifestyle-related diseases, identification of its receptors (AdipoRs), elucidation of AdipoR-mediated signaling pathways that promote healthy longevity and acquisition of small-molecule AdipoR agonist, and explores future prospects on adiponectin-targeted therapy.
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