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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Low serum calcium is associated with left ventricular systolic dysfunction in a Chinese population with coronary

Yong Wang1,2, Heng Ma3, Xiaochen Hao4

  • 1Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Scientific Reports
|March 1, 2016
PubMed

Insights

Serum calcium levels are lower in patients with acute myocardial infarction (AMI) and coronary artery disease (CAD). Low serum calcium is linked to impaired heart systolic function (left ventricular ejection fraction <50%) in these patients.

Area of Science:

  • Cardiology
  • Biochemistry
  • Internal Medicine

Background:

  • Serum calcium's role in heart function, particularly in coronary artery disease (CAD) and acute myocardial infarction (AMI), requires further investigation.
  • Left ventricular systolic dysfunction is a critical complication in CAD and AMI patients.

Purpose of the Study:

  • To investigate the association between serum calcium levels and left ventricular systolic dysfunction in a Chinese population with established CAD, including those with and without AMI.
  • To identify if serum calcium is an independent predictor of AMI and impaired systolic function.

Main Methods:

  • A cross-sectional study involving 5938 CAD patients in China.
  • Evaluation of factors associated with AMI and left ventricular ejection fraction (LVEF).
  • Multivariate analysis, including logistic regression, to determine independent associations.

Main Results:

  • Patients with AMI exhibited significantly lower serum calcium levels compared to those without AMI (2.11 ± 0.13 vs. 2.20 ± 0.10 mmol/l, P < 0.001).
  • Serum calcium was identified as an independent factor correlated with AMI.
  • Lower serum calcium levels were observed in CAD patients with LVEF < 50% compared to those with LVEF ≥ 50%, both with and without AMI.
  • An independent association between serum calcium and LVEF, including LVEF < 50%, was confirmed in CAD patients with and without AMI.

Conclusions:

  • Serum calcium levels decrease significantly following AMI.
  • Low serum calcium is independently associated with left ventricular systolic dysfunction in CAD patients, irrespective of AMI status.
  • These findings suggest serum calcium as a potential biomarker for systolic dysfunction in CAD.

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