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Updated: Mar 25, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Silane modified upconversion nanoparticles with multifunctions: imaging, therapy and hypoxia detection.

Shihan Xu¹, Xinran Zhang¹, Hongwei Xu¹

¹State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.

Scientific Reports

|March 1, 2016

Summary

This summary is machine-generated.

We developed ultrathin silane-coated upconversion nanoparticles (UCNPs@silane) for multifunctional biomedical applications including upconversion imaging, cancer therapy, and oxygen detection. These nanoparticles demonstrate good biocompatibility and drug delivery capabilities.

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Last Updated: Mar 25, 2026

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Published on: May 16, 2022

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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

Published on: November 10, 2017

Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Upconversion nanoparticles (UCNPs) offer unique optical properties for bioimaging.
Developing multifunctional nanoparticles with enhanced biocompatibility and drug delivery is crucial for advanced theranostics.

Purpose of the Study:

To synthesize ultrathin silane-coated UCNPs (UCNPs@silane) for multifunctional biomedical applications.
To integrate chemotherapy drugs and oxygen-sensitive probes for combined cancer therapy and oxygen monitoring.

Main Methods:

Facile synthesis of UCNPs with an ultrathin 1-2 nm silane coating.
Loading of paclitaxel (PTX) for chemotherapy and Platinum (II) octaethylporphine (PtOEP) for oxygen sensing.
In vitro bio-experiments including MTT assays and confocal laser scanning microscopy (CLSM) for therapy efficacy evaluation.

Main Results:

UCNPs@silane exhibited good biocompatibility and enabled hydrophobic molecule loading.
The UCNPs@PTX@silane demonstrated effective cancer therapy and imaging capabilities.
UCNPs@PtOEP@silane allowed sensitive detection of intracellular oxygen concentration changes.

Conclusions:

Ultrathin silane coating enhances UCNP functionality for biomedical applications.
The developed multifunctional nanoparticles show promise for combined cancer therapy and real-time oxygen level monitoring.
This platform offers a sensitive approach for minimally invasive analysis of cellular oxygen dynamics.