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Association between soluble lectin-like oxidized low-density lipoprotein receptor 1 levels and coronary slow flow

Ilker Murat Caglar1, Cem Ozde1, Ismail Biyik2

  • 1Department of Cardiology, Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.

Archives of Medical Science : AMS
|March 1, 2016
PubMed

Insights

Serum levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) were significantly higher in patients with coronary slow flow phenomenon (CSFP). High sLOX-1 may play a role in CSFP development.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Coronary slow flow phenomenon (CSFP) is linked to adverse cardiovascular outcomes, similar to coronary artery disease (CAD).
  • Potential mechanisms include endothelial dysfunction, inflammation, microvascular dysfunction, and atherosclerosis.
  • Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) is implicated in atherosclerosis pathogenesis.

Purpose of the Study:

  • To investigate the association between serum sLOX-1 levels and CSFP.
  • To determine if sLOX-1 is a potential biomarker for CSFP.

Main Methods:

  • Included 40 patients with CSFP and 43 with normal coronary flow pattern (NCFP).
  • Measured coronary blood flow using the Thrombolysis In Myocardial Infarction (TIMI) frame count method.
  • Quantified serum sLOX-1 levels in all participants.

Main Results:

  • Serum sLOX-1 levels were significantly elevated in the CSFP group compared to the NCFP group (1061.80 ±422.20 ng/ml vs. 500.043 ±282.97 ng/ml, p < 0.001).
  • Multivariate logistic regression confirmed a significant association between higher sLOX-1 levels and CSFP (OR: 1.006, 95% CI: 1.002-1.010, p = 0.001).

Conclusions:

  • Serum sLOX-1 levels are significantly higher in patients with CSFP.
  • Elevated sLOX-1 is strongly associated with the presence of CSFP.
  • High sLOX-1 may contribute to the development of CSFP, warranting further investigation.
Abstract

Keywords:
coronary slow flow phenomenonsoluble lectin-like oxidized low-density lipoprotein receptor 1

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