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Functional changes are associated with tracheal structural abnormalities in patients with acromegaly
Gustavo Bittencourt Camilo1, Fernando Silva Guimarães2, Roberto Mogami1
1Post-graduate Program in Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Radiology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Archives of Medical Science : AMS
|March 1, 2016
Summary
Acromegalic patients show tracheal structural abnormalities linked to large airway obstruction indicators. These findings correlate with specific airway measurements but not with reported symptoms like dyspnea or sleepiness.
Area of Science:
- Endocrinology
- Pulmonology
- Radiology
Background:
- Acromegaly is linked to increased mortality, potentially due to pulmonary and sleep disorders.
- Tracheal abnormalities in acromegaly remain understudied.
- This study investigates tracheal structure and its relation to respiratory function in acromegaly.
Purpose of the Study:
- To describe tracheal structural abnormalities in acromegalic patients.
- To correlate these abnormalities with respiratory function.
- To examine associations with clinical data.
Main Methods:
- Cross-sectional study at two university hospitals.
- Twenty acromegalic patients and forty matched controls.
- Assessments included spirometry, forced oscillation technique, CT scans, MMRC, and ESS.
Main Results:
- Acromegalic patients had significantly higher FEF50%/FIF50% ratios compared to controls.
- CT revealed larger differences in tracheal diameters (cervical vs. thoracic) in acromegalic patients.
- FEF50%/FIF50% correlated with mean resistance, cervical tracheal diameter, and Δ tracheal diameters.
Conclusions:
- Acromegalic patients exhibit tracheal structural abnormalities.
- These abnormalities are associated with functional indicators of large airway obstruction (LAO).
- No significant correlation was found between LAO indicators or tracheal diameters and clinical data (MMRC, ESS).
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