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High level of serum cholesteryl ester transfer protein in active hepatitis C virus infection

Kenichi Satoh1, Tomohisa Nagano1, Nobuyoshi Seki1

  • 1Kenichi Satoh, Tomohisa Nagano, Nobuyoshi Seki, Yoichi Tomita, Yuta Aida, Tomonori Sugita, Munenori Itagaki, Satoshi Sutoh, Hiroshi Abe, Yoshio Aizawa, Department of Gastroenterology and Hepatology, Internal Medicine of Jikei University Katsushika Medical Center, Katsushikaku, Tokyo 125-8506, Japan.

World Journal of Hepatology
|March 1, 2016
PubMed

Insights

Cholesteryl ester transfer protein (CETP) is elevated in active hepatitis C virus (HCV) infection, contributing to abnormal lipoprotein metabolism. CETP levels correlate with triglyceride abnormalities in HDL during active HCV infection.

Area of Science:

  • Biochemistry
  • Hepatology
  • Lipid Metabolism

Background:

  • Chronic hepatitis C virus (HCV) infection is associated with dyslipidemia.
  • Cholesteryl ester transfer protein (CETP) plays a key role in lipoprotein metabolism.

Purpose of the Study:

  • To investigate the role of CETP in lipoprotein abnormalities in patients with chronic HCV infection.
  • To compare CETP levels and lipoprotein profiles between patients with active HCV infection and those with eradicated HCV.

Main Methods:

  • Serum CETP concentrations were measured in 110 Japanese patients (55 active HCV, 55 HCV-eradicated).
  • Lipoprotein triglyceride (TG) concentrations were analyzed.
  • Pearson correlations and multiple regression analysis were used to assess the relationship between CETP, HCV status, and TG levels.

Main Results:

  • Serum CETP levels were significantly higher in patients with active HCV infection compared to those with eradicated HCV.
  • Active HCV infection was an independent factor associated with higher CETP levels.
  • Patients with active HCV infection exhibited significantly higher TG concentrations in LDL and HDL.
  • CETP levels strongly correlated with HDL-TG in active HCV infection but not after eradication.

Conclusions:

  • CETP is implicated in the lipoprotein abnormalities observed in chronic HCV infection.
  • Elevated CETP contributes to dyslipidemia in active HCV infection.
Abstract

Keywords:
Case control studyCholesteryl ester transfer proteinHepatitis C virusHigh-density lipoprotein triglycerideLipoprotein metabolism

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