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Updated: Mar 25, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Biomechanics of the anterior cruciate ligament: Physiology, rupture and reconstruction techniques
Christoph Domnick1, Michael J Raschke1, Mirco Herbort1
1Christoph Domnick, Michael J Raschke, Mirco Herbort, Department of Trauma, Hand and Reconstructive Surgery, Westphalian Wilhelms University Muenster, 48149 Muenster, Germany.
Abstract:
The influences and mechanisms of the physiology, rupture and reconstruction of the anterior cruciate ligament (ACL) on kinematics and clinical outcomes have been investigated in many biomechanical and clinical studies over the last several decades. The knee is a complex joint with shifting contact points, pressures and axes that are affected when a ligament is injured. The ACL, as one of the intra-articular ligaments, has a strong influence on the resulting kinematics. Often, other meniscal or ligamentous injuries accompany ACL ruptures and further deteriorate the resulting kinematics and clinical outcomes. Knowing the surgical options, anatomic relations and current evidence to restore ACL function and considering the influence of concomitant injuries on resulting kinematics to restore full function can together help to achieve an optimal outcome.

