Glycosylated Notch and Cancer

Related Experiment Video

Updated: Mar 25, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Shanmugasundaram Pakkiriswami1, Africa Couto2, Usha Nagarajan3

  • 1Department of Biology, University of Western Ontario , London, ON , Canada.

Frontiers in Oncology
|March 1, 2016
PubMed

Insights

Glycosylation of Notch proteins is crucial for cell signaling and development. Aberrant glycosylation of Notch is linked to cancer, impacting tumor growth and spread.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • Glycosylation significantly impacts cell signaling pathways involved in survival and growth.
  • The Notch signaling pathway is essential for cell fate determination in metazoan development.
  • Notch proteins and their ligands undergo glycosylation, affecting their structure and function.

Purpose of the Study:

  • To review the critical role of glycosylated Notch proteins in cancer.
  • To provide recent updates on glycosylation's influence on tumorigenesis and metastasis.

Main Methods:

  • Literature review of glycosylation and Notch signaling.
  • Analysis of studies linking Notch glycosylation to cancer development and progression.

Main Results:

  • Specific sugar moieties (O-fucose, O-glucose, O-xylose) modify Notch proteins.
  • Disruptions in Notch glycosylation are associated with developmental disorders and cancer.
  • Altered glycosylation of Notch proteins contributes to tumor initiation and metastasis.

Conclusions:

  • Glycosylation is a key regulator of Notch protein function.
  • Targeting Notch glycosylation may offer therapeutic strategies for cancer treatment.
Keywords:
Notch signalingepidermal growth factorglycosyltransferasestumorigenesis

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