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Free calcium rise and mitogenesis in glial cells caused by endothelin
S Supattapone1, A W Simpson, C C Ashley
1University Laboratory of Physiology, Oxford, U.K.
Biochemical and Biophysical Research Communications
|December 29, 1989
Abstract:
The peptide endothelin causes a biphasic rise in intracellular free calcium levels in cultured Type-1 astrocytes and C6 glioma cells, suggesting that glial cells may be the physiological target of endothelin in the brain. Endothelin also causes a calcium-dependent increase [3H]thymidine incorporation in primary cultures of rat cerebellum, indicating that, among other possible roles, this peptide may mediate mitogenesis in brain.