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Identification and Clinical Characterization of Children With Benign Ethnic Neutropenia
Michael V Ortiz1, Emily R Meier, Matthew M Hsieh
1*Center for Cancer and Blood Disorders, Children's National Medical Center §Department of Pediatrics, The George Washington School of Medicine and Health Sciences, Washington, DC †Department of Pediatrics, Memorial Sloan Kettering Cancer Center ‡Division of Pediatric Hematology and Oncology, New York Presbyterian/Weill Cornell Medical Center, New York City, NY ∥Indiana Hemophilia and Thrombosis Center, Indianapolis, IN. ¶Molecular and Clinical Hematology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) and National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD.
Abstract:
Benign ethnic neutropenia (BEN) is an asymptomatic condition reported in adults of African and Middle Eastern descent. The clinical description in children is currently lacking. In our urban outpatient pediatric hematology clinic, the median neutrophil count of children with BEN was lower than previous reports in adults at 893×10 cells/L, but increased with older age. There was an equal male to female ratio and 24% of our BEN children reported ethnicities other than African or Middle Eastern. Children with BEN had a clinical course comparable with other healthy children including otherwise normal blood counts, except for mild anemia.
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