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Longitudinal changes in adiponectin multimer levels in preterm infants.

Yuya Nakano¹, Kazuo Itabashi¹, Kazushige Dobashi¹

¹Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Early Human Development

|March 2, 2016

Summary

This summary is machine-generated.

Preterm infants show declining levels of total adiponectin (T-Ad) and high-molecular-weight adiponectin (HMW-Ad) by 12 months. Early HMW-Ad levels in preterm infants significantly predict later changes, suggesting developmental programming.

Keywords:

Adiponectin Infancy Longitudinal changes Preterm infants

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Area of Science:

Neonatal research
Endocrinology
Metabolic syndrome

Background:

Preterm infants exhibit altered adiponectin levels at term-equivalent age.
These infants face an increased risk of metabolic syndrome components later in life.

Purpose of the Study:

To track longitudinal changes in adiponectin levels in preterm infants.
To compare adiponectin levels between preterm and term infants over time.

Main Methods:

A cohort study involving 42 preterm infants (≤34-week gestation) and 43 term infants.
Serum total adiponectin (T-Ad) and high-molecular-weight adiponectin (HMW-Ad) measured at term-, 6-month, and 12-month equivalent ages in preterm infants.
Longitudinal data from term infants were reviewed for comparison.

Main Results:

Both T-Ad and HMW-Ad levels decreased by 12 months in preterm infants, mirroring term infant patterns.
The ratio of HMW-Ad to T-Ad differed between groups at 6 months but normalized by 12 months.
Early HMW-Ad levels at term-equivalent age were the sole significant predictor of HMW-Ad changes up to 12 months in preterm infants.

Conclusions:

High-molecular-weight adiponectin levels decrease throughout infancy in both term and preterm infants.
Adiponectin level changes in preterm infants during infancy may be influenced by factors present up to term-equivalent age.