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Sprue-like enteropathy linked to olmesartan
Amaia Campos Ruiz1, Leire Urtasun Arlegui2, Carlos Marra-López Valenciano2
1Aparato Digestivo, Hospital Universitario de Álava, España.
Revista Espanola De Enfermedades Digestivas
|March 2, 2016
Summary
Olmesartan medication can cause a sprue-like enteropathy, mimicking celiac disease. Discontinuing olmesartan typically resolves this gastrointestinal condition, highlighting its importance in differential diagnosis.
Area of Science:
- Gastroenterology
- Internal Medicine
- Pharmacology
Background:
- Olmesartan, an angiotensin II receptor blocker, is a common hypertension treatment.
- Sprue-like enteropathy associated with olmesartan was first identified in 2012.
- This condition presents with villous atrophy, resembling celiac disease.
Observation:
- Two cases of olmesartan-induced sprue-like enteropathy were diagnosed.
- Both patients had a history of over one year of olmesartan treatment.
- Biopsies revealed duodenal villous atrophy with negative celiac disease serology.
Findings:
- Patients experienced significant improvement after discontinuing olmesartan.
- Histopathological findings mimicked celiac disease but lacked serological markers.
- Clinical remission was observed upon medication cessation.
Implications:
- Olmesartan-associated sprue-like enteropathy is a crucial consideration in seronegative villous atrophy.
- Early diagnosis and discontinuation of olmesartan can lead to favorable patient outcomes.
- This highlights the importance of medication history in diagnosing enteropathies.
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