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Ulcerative Colitis Is Under Dual (Mitochondrial and Nuclear) Genetic Control

Alexandra Rosa1, Patrícia Abrantes, Inês Sousa

  • 1*Unidade de Ciências Médicas, Centro de Competências das Ciências da Vida, Universidade da Madeira, Funchal, Portugal; †Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; ‡Instituto Gulbenkian de Ciência, Oeiras, Portugal; and §Centre for Biomedical Research (CBMR), Universidade do Algarve, Faro, Portugal.

Inflammatory Bowel Diseases
|March 2, 2016
PubMed
Summary

Mitochondrial DNA (mtDNA) variations, specifically the A10550G variant, significantly increase ulcerative colitis (UC) risk. This study reveals dual genetic control of UC involving both nuclear and mitochondrial genomes.

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