Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

18.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
18.3K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

9.0K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
9.0K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Inflammatory Response01:28

Inflammatory Response

18.4K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
18.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotypic characterization of immune cells in fetal tissues of cattle immunized and challenged with Neospora caninum.

Veterinary immunology and immunopathology·2019
Same author

Changes and specificities in health behaviors among healthcare students over an 8-year period.

PloS one·2018
Same author

Polyploidy and habitat differentiation in Dactylis glomerata L. from Galicia (Spain).

Oecologia·2017
Same author

Expression of Kidney Injury Molecule-1 in Healthy and Diseased Feline Kidney Tissue.

Veterinary pathology·2017
Same author

Perianesthetic Mortality in Domestic Animals: A Retrospective Study of Postmortem Lesions and Review of Autopsy Procedures.

Veterinary pathology·2016
Same author

Characterization of kidney injury molecule-1 in cats.

Journal of veterinary internal medicine·2014

Related Experiment Video

Updated: Mar 25, 2026

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
08:24

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Published on: November 18, 2016

11.8K

Thrombomodulin Expression in Tissues From Dogs With Systemic Inflammatory Disease.

S D Kim1, P Baker1, J DeLay2

  • 1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Veterinary Pathology
|March 2, 2016
PubMed
Summary
This summary is machine-generated.

Inflammation significantly reduces thrombomodulin (TM) expression in canine tissues. This study found lower TM levels in dogs with systemic inflammatory diseases, highlighting potential risks for thrombosis.

Keywords:
canineinflammationliverlungsepsisspleensystemic inflammatory response syndromethrombomodulin

More Related Videos

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

9.0K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K

Related Experiment Videos

Last Updated: Mar 25, 2026

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
08:24

Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

Published on: November 18, 2016

11.8K
Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood
07:08

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Published on: September 5, 2017

9.0K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K

Area of Science:

  • Veterinary Pathology
  • Immunohistochemistry
  • Endothelial Biology

Background:

  • Thrombomodulin (TM) is a key glycoprotein in the protein C pathway, crucial for anticoagulation.
  • Inflammation in humans down-regulates endothelial TM expression, increasing thrombosis risk.
  • Canine TM expression and inflammatory effects remain understudied.

Purpose of the Study:

  • To investigate endothelial TM expression in canine tissues.
  • To assess the impact of systemic inflammation on TM levels in dogs.

Main Methods:

  • Retrospective analysis of lung, spleen, and liver tissues from dogs with and without systemic inflammation.
  • Immunohistochemistry (IHC) utilized for TM expression evaluation.
  • A modified manual IHC scoring system applied for quantification.

Main Results:

  • Endothelial TM expression was significantly reduced in all examined tissues.
  • Reduced TM expression observed in dogs with septic peritonitis and acute pancreatitis.

Conclusions:

  • Systemic inflammatory diseases in dogs are associated with decreased endothelial TM expression.
  • This reduction may contribute to an increased risk of thrombotic events in affected dogs.