Related Experiment Video

Updated: Mar 25, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

20.3K

Simultaneous Longitudinal Strain in All 4 Cardiac Chambers: A Novel Method for Comprehensive Functional Assessment of

Karima Addetia1, Masaaki Takeuchi2, Francesco Maffessanti2

  • 1From the Department of Medicine, Section of Cardiology, University of Chicago, IL (K.A., F.M., V.M.-A., R.M.L.); School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan (M.T., Y.N.); and Epsilon Imaging, Ann Arbor, MI (J.H.). kaddetia@medicine.bsd.uchicago.edu.

Circulation. Cardiovascular Imaging
|March 2, 2016
PubMed

Insights

Simultaneous longitudinal strain (LS) assessment in all four heart chambers reveals distinct functional relationships. This novel echocardiography technique offers insights into cardiac chamber dynamics and potential disease evaluation.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Mechanics

Background:

  • Simultaneous assessment of longitudinal strain (LS) across all four cardiac chambers using 2D speckle-tracking echocardiography (STE) remains unexplored.
  • Understanding interchamber functional relationships is crucial for comprehensive cardiac assessment.

Purpose of the Study:

  • To investigate LS curves obtained simultaneously from all four cardiac chambers in healthy individuals.
  • To gain insights into the functional interrelationships between the left atrium, left ventricle, right atrium, and right ventricle.

Main Methods:

  • Studied 259 healthy subjects using 2D STE to acquire apical 4-chamber views encompassing all four chambers.
  • Measured LS over time, including peak LS and time-to-peak strain, for all chambers within a single cardiac cycle.
  • Utilized vendor-independent software for LS analysis, incorporating septal contributions to atrial and ventricular measurements.

Main Results:

  • Right ventricular and right atrial LS curves exhibited larger magnitudes and shorter time-to-peak values compared to the left side.
  • Ventricular LS consistently peaked earlier than atrial LS within the same chamber.
  • Peak systolic LS was higher in women than men; atrial LS decreased with age, while right ventricular free-wall LS increased until the sixth decade.

Conclusions:

  • Simultaneous LS measurement provides novel insights into interchamber functional dynamics.
  • This technique serves as a valuable tool for assessing cardiac conditions affecting chambers disparately.
  • Further research can explore the clinical utility of this comprehensive LS assessment in various cardiovascular diseases.
Abstract

Keywords:
atrial functioncardiac functionlongitudinal strainstrainventricular function

More Related Videos

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

24.8K
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

7.4K

Related Concept Videos

Chambers of the Heart01:16

Chambers of the Heart

The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
11.2K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
671
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
122.4K