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Antiangiogenic Resistance: Novel Angiogenesis Axes Uncovered by Antiangiogenic Therapies Research

Gabriela Jiménez-Valerio, Oriol Casanovas1

  • 1Tumor Angiogenesis Group, Catalan Institute of Oncology-IDIBELL, Av. Gran Via de l'Hospitalet 199- 203 (3rd floor), E-08908 L'Hospitalet de Llobregat, Barcelona, Spain.

Current Drug Targets
|March 2, 2016
PubMed

Insights

Tumor growth relies on angiogenesis, but cancer cells can resist anti-angiogenic therapies. Strategies are being developed to overcome both intrinsic and acquired resistance to these treatments.

Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Tumor growth and progression are complex processes involving neovascularization and angiogenesis.
  • Angiogenesis, driven by tumoral and stromal cells, is crucial for tumor expansion and proliferation.
  • Anti-angiogenic therapies target this process but face challenges due to tumor resistance.

Purpose of the Study:

  • To explore the mechanisms of tumor resistance to anti-angiogenic therapies.
  • To review strategies aimed at preventing or overcoming both intrinsic and acquired resistance.
  • To highlight ongoing research and clinical trials focused on enhancing anti-angiogenic treatment efficacy.

Main Methods:

  • Review of preclinical studies investigating resistance mechanisms.
  • Analysis of clinical trial data on anti-angiogenic therapies.
  • Examination of proposed strategies to combat tumor resistance.

Main Results:

  • Tumoral and stromal cells contribute significantly to resistance against anti-angiogenic treatments.
  • Tumors exhibit both intrinsic (pre-existing) and acquired (treatment-induced) resistance.
  • A majority of tumors initially respond, but resistance remains a significant clinical challenge.

Conclusions:

  • Overcoming resistance is critical for improving the effectiveness of anti-angiogenic therapies in cancer treatment.
  • Developing novel strategies to prevent or delay resistance is an active area of research.
  • Continued investigation through preclinical and clinical studies is essential to combat tumor resistance.

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