Related Experiment Video
Updated: Mar 24, 2026
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Association between Asthma and Primary Nocturnal Enuresis in Children
Patricia Dahan1, José de Bessa2, Dayana Maria de Oliveira3
1Department of Pediatrics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil; Department of Pediatrics, School of Medicine of University Presidente Antônio Carlos, Barbacena, Brazil.
Insights
Asthma and sleep respiratory disorders are linked to primary nocturnal enuresis in children. Children with asthma and wheezing are more likely to experience enuresis, and enuretic children show higher rates of sleep apnea.
Area of Science:
- Pediatric Sleep Medicine
- Respiratory Medicine
- Urology
Background:
- Sleep disturbances like enuresis, sleep-disordered breathing, and asthma negatively impact children's quality of life.
- Previous research established a link between sleep-disordered breathing and enuresis.
- The united airways disease hypothesis suggests co-occurring upper and lower airway conditions.
Purpose of the Study:
- To investigate the potential association between asthma and primary nocturnal enuresis in children.
- To explore if conditions like wheezing, snoring, and obstructive sleep apnea are linked to enuresis.
Main Methods:
- A cross-sectional study involving 523 children aged 6-14 from 16 elementary schools.
- Exclusion criteria included non-monosymptomatic enuresis and urological/neurological conditions.
- The Tucson questionnaire assessed sleep-disordered breathing, and the ISAAC questionnaire assessed asthma.
Main Results:
- The prevalence of enuresis was 15.87% in the study population.
- Children with asthma and recent wheezing were 2.33 times more likely to have a history of enuresis.
- Enuretic children were 5.34 times more likely to have parental-reported sleep apnea.
Conclusions:
- Asthma is significantly associated with primary nocturnal enuresis in children.
- Sleep-disordered breathing, including sleep apnea, is also linked to primary nocturnal enuresis.
- These findings highlight the interconnectedness of respiratory and sleep issues in pediatric enuresis.
Purpose:
Enuresis, sleep respiratory disorders and asthma compromise the quality of sleep in children and may occur in association with each other. An association between sleep respiratory disorders and enuresis has already been demonstrated. According to united airways disease abnormalities of the upper and lower airways may coexist. A child who wheezes has a greater chance of snoring and having obstructive sleep apnea. Since asthma and sleep respiratory disorders may be associated, and sleep respiratory disorders are associated with enuresis, we determined the possibility of an association between asthma and enuresis.
Materials And Methods:
Between August 20 and March 2015 parents/guardians of children 6 to 14 years old from 16 elementary schools in our area were randomly chosen for study. Children with nonmonosymptomatic enuresis and urological or neurological disease were excluded. The Tucson and ISAAC (International Study of Asthma and Allergies in Childhood) questionnaires were used to assess sleep respiratory disorders and asthma, respectively.
Results:
A total of 523 children (283 males and 240 females) with a mean ± SD age of 9.42 ± 2.46 years were included in analysis. The overall prevalence of enuresis was 15.87% (95% CI 12.98-19.26). Asthmatic children with wheezing in the last 12 months were 2.33 times more likely to have had enuresis at some point in life (OR 2.33, 95% CI 1.37-3.95, p = 0.0017). If enuresis was present, the chance increased to 2.78 (95% CI 1.38-5.61, p = 0.0041). Enuretic children were 5.34 times more prone to have apnea reported by parents (95% CI 2.19-13.03, p = 0.0002).
Conclusions:
These findings demonstrate that asthma as well as sleep respiratory disorders is associated with primary nocturnal enuresis.
More Related Videos
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:26The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
01:24Asthma-III: Symptoms and Complications
Classification of Asthma
01:29Asthma-I: Introduction
01:18Nightmares and Night Terrors
Nightmares...
01:26Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include: