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Platelets as Biomarkers of Coronary Artery Disease

Leonardo Pasalic1, Samuel S Y Wang2, Vivien M Y Chen1

  • 1Prince of Wales Clinical School, Adult Cancer Program, University of New South Wales, Sydney, Australia.

Seminars in Thrombosis and Hemostasis
|March 2, 2016
PubMed

Insights

Platelet-derived biomarkers show promise for assessing cardiovascular disease risk. This review explores their potential and limitations in improving patient prognostication and guiding preventative care strategies.

Area of Science:

  • Cardiovascular medicine
  • Hematology
  • Biomarker research

Background:

  • Cardiovascular disease prevention is a major public health concern.
  • Accurate patient risk stratification is essential for effective preventative strategies.
  • Platelets are implicated in thrombosis, atherogenesis, and angiogenesis, making them attractive targets for biomarker development.

Purpose of the Study:

  • To review the potential of platelet-based assays as biomarkers for coronary artery disease.
  • To assess the limitations of current platelet-derived biomarkers.
  • To evaluate their role in risk stratification for cardiovascular disease prevention.

Main Methods:

  • Literature review of studies on platelet-derived biomarkers.
  • Analysis of various platelet-based assays.
  • Assessment of biomarker performance in coronary artery disease prognostication.

Main Results:

  • Platelet-derived biomarkers offer a promising avenue for cardiovascular disease risk assessment.
  • Several assays show potential for improving patient prognostication.
  • Limitations exist regarding standardization, validation, and clinical implementation.

Conclusions:

  • Platelet-based assays hold significant potential for enhancing cardiovascular disease risk stratification.
  • Further research and validation are needed to overcome current limitations.
  • These biomarkers could play a crucial role in guiding preventative interventions for coronary artery disease.

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