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Related Concept Videos

Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids
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Hypoxia-Sensitive Materials for Biomedical Applications.

Jicheng Yu1,2, Yuqi Zhang1,2, Xiuli Hu3

  • 1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.

Annals of Biomedical Engineering
|March 2, 2016
PubMed
Summary
This summary is machine-generated.

Hypoxia, a hallmark of diseases like cancer and stroke, necessitates targeted diagnostic and therapeutic strategies. This review explores hypoxia-responsive systems, focusing on HIF-1 and bioreductive approaches for improved disease management.

Keywords:
BioimagingBioreductive moleculeDrug deliveryHypoxia inducible factor-1Hypoxia-responsive

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Neurology

Background:

  • Hypoxia is a common characteristic of various diseases, including cancer, ischemic diseases, and stroke.
  • Hypoxia is often linked to disease progression, highlighting the need for targeted interventions.
  • Effective strategies are crucial for diagnosing and treating hypoxic regions.

Purpose of the Study:

  • To review recent advancements in hypoxia-responsive systems for medical applications.
  • To discuss two main types of hypoxia-sensitive systems: hypoxia-inducible factor-1 (HIF-1) based and bioreductive molecule based systems.
  • To analyze the advantages and limitations of these systems and explore future opportunities and challenges.

Main Methods:

  • Literature review of recent progress in hypoxia-responsive systems.
  • Categorization and analysis of systems based on HIF-1 and bioreductive molecules.
  • Discussion of system applications in imaging, sensing, and therapy.

Main Results:

  • Recent progress in developing hypoxia-responsive systems for imaging, sensing, and therapy is summarized.
  • Hypoxia-inducible factor-1 (HIF-1) based systems and bioreductive molecule based systems are discussed.
  • Advantages and limitations of each system type are commented upon.

Conclusions:

  • Hypoxia-responsive systems offer promising avenues for targeted diagnosis and treatment of diseases.
  • Further research into HIF-1 and bioreductive systems can overcome current limitations.
  • Continued development is essential to fully exploit these systems for clinical applications.