Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.9K
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.6K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.6K
Physiology of Emotion01:20

Physiology of Emotion

4.2K
The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
4.2K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

105.6K
Overview
105.6K
Physiological Theories: Cannon-Bard Theory of Emotion01:22

Physiological Theories: Cannon-Bard Theory of Emotion

2.1K
The Cannon-Bard theory of emotion, proposed by Walter Cannon and Philip Bard, challenges the notion that emotions are solely the result of physiological responses. Instead, this theory suggests that emotional experiences and physiological arousal occur simultaneously but operate through independent mechanisms. This dual response is initiated by the brain, specifically by the thalamus, which plays a critical role in processing sensory information.
Upon perceiving a stimulus, such as a dangerous...
2.1K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

69.9K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
69.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying Skin Sodium Concentration With Novel Very Rapid Biexponential T<sub>2</sub> Relaxometry and Signal Loss Compensation Methodology.

Magnetic resonance in medicine·2026
Same author

Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan.

NMR in biomedicine·2026
Same author

Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.

NMR in biomedicine·2026
Same author

<i>Erratum</i> to: "Isatuximab plus bortezomib, lenalidomide, and dexamethasone for transplant-ineligible newly diagnosed multiple myeloma patients: a frailty subgroup analysis of the IMROZ trial".

Haematologica·2026
Same author

Laterally Oscillating Trajectory for Undersampling Slices: LOTUS.

Magnetic resonance in medicine·2026
Same author

AI-assisted teams outperform AI-led teams but not human-only teams in assessing research reproducibility in quantitative social science.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Mar 24, 2026

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
14:04

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

13.3K

Amygdala subnuclei response and connectivity during emotional processing.

Stanislau Hrybouski1, Arash Aghamohammadi-Sereshki1, Christopher R Madan2

  • 1Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Neuroimage
|March 2, 2016
PubMed
Summary

This study reveals functional specialization within the human amygdala. The centromedial amygdala shows heightened responsiveness to negative emotional stimuli, indicating distinct roles for amygdala subnuclei in emotion processing.

Keywords:
Amygdala connectivityAmygdala subnucleiEmotionsHigh-resolution fMRI

More Related Videos

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection
11:30

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

10.4K
How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
10:48

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

Published on: June 3, 2013

22.9K

Related Experiment Videos

Last Updated: Mar 24, 2026

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
14:04

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

13.3K
Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection
11:30

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

10.4K
How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
10:48

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

Published on: June 3, 2013

22.9K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Psychology

Background:

  • The human amygdala's role in emotion processing is extensively studied using fMRI.
  • Previous research often treated the amygdala as a whole, overlooking subnuclear specializations.

Purpose of the Study:

  • To investigate the functional responsiveness of human amygdala subnuclei to negative emotional stimuli.
  • To explore intra-amygdala functional connectivity patterns.

Main Methods:

  • Combined a novel anatomical tracing protocol with event-related, high-resolution fMRI.
  • Analyzed hemodynamic response amplitude and latency in amygdala subnuclei.

Main Results:

  • The centromedial amygdala exhibited the greatest sensitivity to negative emotional stimuli.
  • Hemodynamic response amplitude was greater and peaked later in the centromedial amygdala for negative versus neutral stimuli.
  • Connectivity patterns showed the centromedial amygdala more connected to basal amygdala nuclei than lateral amygdala.

Conclusions:

  • Provides evidence for functional specialization within the human amygdala.
  • Highlights the distinct role of the centromedial amygdala in processing negative emotions.
  • Supports animal findings on amygdala subnuclear connectivity in humans.