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Resisting resistance: is there a solution for malaria?
Bianca K Verlinden1, Abraham Louw1, Lyn-Marié Birkholtz1
1a Department of Biochemistry, Centre for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences , University of Pretoria , Pretoria , South Africa.
Expert Opinion on Drug Discovery
|March 2, 2016
Summary
Antimalarial drug resistance is a growing problem, necessitating new discovery strategies. Lessons from antibiotic and cancer research can help develop longer-lasting malaria treatments.
Area of Science:
- Malariology
- Drug Discovery
- Parasitology
Background:
- Widely used antimalarial drugs face limited clinical efficacy due to increasing Plasmodium parasite resistance.
- Rising antimalarial drug resistance necessitates novel discovery approaches to ensure sustained therapeutic lifespans.
Purpose of the Study:
- To review current strategies for circumventing malaria parasite resistance.
- To explore alternative approaches for antimalarial drug discovery.
Main Methods:
- Literature review of current antimalarial resistance strategies.
- Examination of cross-disciplinary insights from antibiotic and cancer chemotherapy resistance studies.
Main Results:
- Existing antimalarial drugs have diminishing lifespans due to resistance.
- Alternative strategies are crucial for sustained antimalarial drug development.
Conclusions:
- Novel antimalarial drug discovery must incorporate anti-resistance strategies.
- Insights from other therapeutic fields can accelerate the development of effective antimalarials to combat resistance.
