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Updated: Mar 24, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New bioactive labdane diterpenoids from Marrubium aschersonii
Saoussen Hammami1, Zhenzhen Li2, Mingjie Huang2
1a Research Unit Applied Chemistry and Environment 13ES63, Faculty of Sciences of Monastir , Monastir University , Monastir , Tunisia.
Abstract:
A phytochemical investigation of the ethanol extract of Marrubium aschersonii Magnus (Lamiaceae) collected from Tunisia led to the isolation and identification of two new labdane diterpenoids, marrubaschs A (1) and B (2), along with two known compounds (3 and 4). Their structures were elucidated by spectroscopic methods including HRESIMS and NMR techniques. All compounds were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compound 2 exhibited weak inhibition of NO production with an IC50 value of 35 ± 1.0 μM.
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