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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
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[Hyperleptinemia associated with ischemic stroke]
Jorge Luis García-Sánchez1, Nayeli Gabriela Jiménez-Saab2, Jesús Guerrero-González3
1Servicio de Medicina Interna, Hospital General Ticomán, Secretaría de Salud del Distrito Federal, México, D.F., México.
Gaceta Medica De Mexico
|March 2, 2016
Summary
Hyperleptinemia, or elevated leptin levels, is more common in patients experiencing stroke and systemic arterial hypertension (SAH). Further research is needed to determine if high leptin is a risk or protective factor for stroke.
Area of Science:
- Endocrinology
- Cardiovascular Science
- Neurology
Context:
- Stroke is a leading cause of death and disability, with risk factors including obesity, diabetes, hypertension, and dyslipidemia.
- Leptin, an adipokine regulating energy balance, is increasingly linked to cardiovascular disease.
- Systemic arterial hypertension (SAH) is a major risk factor for stroke.
Purpose:
- To investigate the association between serum leptin levels and stroke in patients diagnosed with SAH.
Summary:
- Serum leptin was measured in 60 patients with SAH, comparing 30 with stroke to 30 without stroke.
- Hyperleptinemia (defined as leptin >3.93 ng/ml) was significantly more prevalent in the stroke group (p=0.001).
- Elevated leptin was associated with an odds ratio of 3.05 for stroke development in SAH patients (p=0.05).
Impact:
- Findings suggest a higher prevalence of hyperleptinemia in SAH patients with stroke.
- This study highlights the need for further investigation into leptin's role as a potential risk or protective factor in stroke pathogenesis.
- Understanding leptin's influence could lead to novel therapeutic strategies for stroke prevention and management in hypertensive individuals.
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