Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization.

Journal of the American Chemical Society·2018
Same author

The Weak-Link Approach to the Synthesis of Inorganic Macrocycles.

Angewandte Chemie (International ed. in English)·2018
Same author

Ligand Design for Electrochemically Controlling Stoichiometric and Catalytic Reactivity of Transition Metals.

Angewandte Chemie (International ed. in English)·2018
Same author

The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA.

Angewandte Chemie (International ed. in English)·2018
Same author

Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks.

Angewandte Chemie (International ed. in English)·2018
Same author

PLGA Spherical Nucleic Acids.

Advanced materials (Deerfield Beach, Fla.)·2018

Related Experiment Video

Updated: Mar 24, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

15.1K

Hard Transparent Arrays for Polymer Pen Lithography.

James L Hedrick, Keith A Brown1, Edward J Kluender

  • 1Department of Mechanical Engineering and Division of Materials Science & Engineering, Boston University , 110 Cummington Mall, Boston, Massachusetts 02215, United States.

ACS Nano
|March 2, 2016
PubMed
Summary

Researchers developed a new silica coating for polymer pen lithography, enabling high-resolution nanoscale patterning over large areas. This advancement significantly improves feature size, pitch, and uniformity for applications in nanocombinatorics.

Keywords:
atomic force microscopydip-pen nanolithographyplasma-enhanced chemical vapor depositionpolydimethylsiloxanepolymer pen lithographyscanning probe lithography

More Related Videos

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
10:09

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

8.7K
Capillary Force Lithography for Cardiac Tissue Engineering
10:09

Capillary Force Lithography for Cardiac Tissue Engineering

Published on: June 10, 2014

13.0K

Related Experiment Videos

Last Updated: Mar 24, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

15.1K
Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
10:09

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers

Published on: June 30, 2018

8.7K
Capillary Force Lithography for Cardiac Tissue Engineering
10:09

Capillary Force Lithography for Cardiac Tissue Engineering

Published on: June 10, 2014

13.0K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Lithography

Background:

  • Patterning nanoscale features over large areas presents significant challenges due to scale disparities.
  • Traditional polymer pen lithography (PPL) using soft elastomeric pens faces limitations in resolution and feature pitch, particularly with polymeric inks, due to pen deformation.

Purpose of the Study:

  • To enhance the patterning capabilities of polymer pen lithography for high-resolution, large-area fabrication.
  • To overcome the resolution and uniformity limitations of conventional PPL by modifying the pen array structure.

Main Methods:

  • Coating arrays of elastomeric pyramidal pens with a thin silica layer (∼175 nm).
  • Utilizing the modified hard, transparent pen arrays for nanoscale feature writing.
  • Demonstrating patterning of feature size gradients.

Main Results:

  • The silica coating resulted in a force-independent contact area, improving patterning precision.
  • Achieved a minimum feature size of ∼40 nm and a minimum feature pitch below 200 nm for polymer inks.
  • Successfully patterned 5.9 billion features over a 14.5 cm² area and created macroscopic feature size gradients.

Conclusions:

  • Silica-coated polymer pen arrays offer a significant advancement in high-resolution, large-area nanoscale patterning.
  • The technique achieves the resolution of dip-pen nanolithography at centimeter scales with simple, inexpensive arrays.
  • This high-resolution, high-density patterning method is a valuable tool for nanocombinatorics and other discovery applications.