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Evaluation of the Storage Stability of Extracellular Vesicles
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Extracellular vesicles for drug delivery.

Pieter Vader1, Emma A Mol2, Gerard Pasterkamp3

  • 1Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Advanced Drug Delivery Reviews
|March 2, 2016
PubMed
Summary
This summary is machine-generated.

Extracellular vesicles (EVs) offer promising drug delivery potential due to their natural properties. However, scalable isolation and efficient drug loading remain key challenges for therapeutic applications.

Keywords:
Extracellular vesiclesbiodistributiondrug deliveryexosomesisolationmicrovesiclesnanomedicinetargeting

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cell Biology

Background:

  • Extracellular vesicles (EVs) are natural intercellular communicators.
  • EVs can transfer biological information and possess drug delivery advantages like barrier crossing and stability.

Purpose of the Study:

  • To review recent advancements in developing EVs for drug delivery.
  • To discuss the challenges hindering therapeutic applications of EVs.

Main Methods:

  • Review of current literature on EV isolation, drug loading, and engineering.
  • Analysis of EV properties relevant to drug delivery systems.

Main Results:

  • EVs show potential for overcoming biological barriers and offer inherent targeting.
  • Scalable isolation and efficient drug loading methods are currently lacking.
  • EV engineering is necessary to optimize cell targeting for drug delivery.

Conclusions:

  • Significant progress has been made in utilizing EVs for drug delivery.
  • Further research is needed to address scalability, loading efficiency, and targeted delivery for clinical translation.