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Prescription patterns, adherence and characteristics of non-adherence in children with asthma in primary care

Marjolein Engelkes1, Hettie M Janssens2, Johan C de Jongste2

  • 1Department of Medical Informatics, Erasmus University, Rotterdam, The Netherlands.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|March 2, 2016
PubMed

Insights

Asthma medication adherence in children is crucial. In Dutch primary care, inhaled corticosteroid adherence was low, suggesting it

Area of Science:

  • Pediatric Pulmonology
  • Real-world Evidence in Asthma Management
  • Medication Adherence Research

Background:

  • Effective asthma management in children hinges on consistent treatment adherence.
  • Understanding real-world medication use and adherence patterns is key to improving pediatric asthma care.

Purpose of the Study:

  • To investigate prescription trends for asthma medications in children.
  • To assess adherence rates to asthma drugs in pediatric populations.
  • To identify factors associated with medication adherence in children with asthma.

Main Methods:

  • A population-based cohort study utilized Dutch primary care database records (IPCI) from 2000-2012.
  • Included 176,516 children aged 5-18 years, analyzing asthma medication prescriptions.
  • Adherence was measured using Medication Possession Ratio (MPR) and Controller to Total drug ratio (CTT).

Main Results:

  • The asthma cohort (n=14,303) primarily received short-acting beta-agonists (SABA) and inhaled corticosteroids (ICS).
  • Median MPR for ICS was 56%, indicating relatively low adherence.
  • Children with high ICS adherence (MPR > 87%) were younger, had more specialist visits, and experienced more exacerbations.

Conclusions:

  • Dutch primary care predominantly prescribed SABA and ICS for pediatric asthma.
  • Adherence to inhaled corticosteroids (ICS) among children with asthma was found to be low.
  • Good adherence correlated with indicators of more severe asthma, suggesting adherence is linked to treatment necessity and medical follow-up intensity.
Abstract

Keywords:
asthma treatmentcohort studypaediatric asthmaprescription patternstreatment adherence

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