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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
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Synthesis of Phosphatidylcholine in the ER Membrane01:27

Synthesis of Phosphatidylcholine in the ER Membrane

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The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
The major components of all eukaryotic cell...
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Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

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Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
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Related Experiment Video

Updated: Mar 24, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
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Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

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Cholesterol in platelet biogenesis and activation.

Nan Wang1, Alan R Tall1

  • 1Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center, New York, NY.

Blood
|March 2, 2016
PubMed
Summary

High cholesterol (hypercholesterolemia) affects platelet production and function, increasing risks for atherosclerosis and thrombosis. Understanding these impacts is crucial for managing cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Metabolic Disease Research

Background:

  • Hypercholesterolemia is a significant risk factor for atherothrombotic diseases.
  • Macrophages within atherosclerotic lesions are key cellular players.
  • Platelets play critical roles in immunity, inflammation, and atherogenesis.

Purpose of the Study:

  • To review recent findings on how abnormal cholesterol metabolism affects platelet biogenesis and activity.
  • To explore the relevance of these platelet changes in atherosclerosis and thrombosis.

Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of studies investigating cholesterol metabolism and platelet function.
  • Synthesis of evidence linking platelet changes to atherosclerosis and thrombosis.

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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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Related Experiment Videos

Last Updated: Mar 24, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
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Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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Main Results:

  • Aberrant cholesterol metabolism influences platelet production (biogenesis) and functional capacity.
  • Altered platelet activity due to hypercholesterolemia contributes to atherogenesis.
  • Hypercholesterolemia exacerbates thrombosis risk through platelet modulation.

Conclusions:

  • Dysregulated cholesterol metabolism critically impacts platelet biology.
  • Platelet alterations driven by hypercholesterolemia are central to the development of atherosclerosis and thrombosis.
  • Targeting cholesterol's effect on platelets may offer therapeutic strategies for cardiovascular disease.