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Cholesterol in platelet biogenesis and activation

Nan Wang1, Alan R Tall1

  • 1Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center, New York, NY.

Blood
|March 2, 2016
PubMed

Hypercholesterolemia is a risk factor for atherothrombotic disease, largely attributed to its impact on atherosclerotic lesional cells such as macrophages. Platelets are involved in immunity and inflammation and impact atherogenesis, primarily by modulating immune and inflammatory effector cells. There is evidence that hypercholesterolemia increases the risk of atherosclerosis and thrombosis by modulating platelet biogenesis and activity. This review highlights recent findings on the impact of aberrant cholesterol metabolism on platelet biogenesis and activity and their relevance in atherosclerosis and thrombosis.

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