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Published on: July 22, 2012
Epidemics of Norovirus GII.4 Variant in Outbreak Cases in Korea, 2004-2012
Sunyoung Jung1, Hyun Ju Jeong1, Bo-Mi Hwang1
1Division of Enteric Diseases, Center for Infectious Diseases, Korea National Institute of Health, Osong, Korea.
Abstract:
Norovirus GII.4 is recognized as a worldwide cause of nonbacterial outbreaks. In particular, the GII.4 variant occurs every 2-3 years according to antigenic variation. The aim of our study was to identify GII.4 variants in outbreaks in Korea during 2004-2012. Partial VP1 sequence of norovirus GII.4-related outbreaks during 2004-2012 was analyzed. The partial VP1 sequence was detected with reverse transcription-polymerase chain reaction, seminested polymerase chain reaction, and nucleotide sequence of 312-314 base pairs for phylogenetic comparison. Nine variants emerged in outbreaks, with the Sydney variant showing predominance recently. This predominance may persist for at least 3 years, although new variants may appear in Korea.
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