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Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: Mar 24, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hydrogels for ocular drug delivery and tissue engineering.

Marzieh Fathi¹, Jaleh Barar¹, Ayuob Aghanejad¹

¹Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Bioimpacts : BI

|March 2, 2016

Summary

Hydrogels offer promising applications in drug delivery and tissue engineering. This study highlights their potential for prolonged intraocular drug delivery and ocular surface therapy using stem cells.

Keywords:

Cell therapy Drug delivery Eye Hydrogels Ocular diseases Tissue engineering

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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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Area of Science:

Biomaterials Science
Ophthalmology
Regenerative Medicine

Background:

Hydrogels are crosslinked polymeric networks with unique stimulus-responsive properties.
They have significant potential in drug delivery, cell therapy, and tissue engineering.

Purpose of the Study:

To explore the potential of hydrogels for prolonged intraocular drug delivery.
To investigate the use of stem cell-incorporated hydrogels for ocular surface therapy.

Main Methods:

Utilizing hydrogels as three-dimensional polymeric networks.
Incorporating stem cells within hydrogel structures.

Main Results:

Hydrogels exhibit unique structures and behaviors responsive to stimuli.
Demonstrated potential for sustained drug release within the eye.
Showcased efficacy in ocular surface regeneration applications.

Conclusions:

Hydrogels are versatile biomaterials with significant promise for advanced ophthalmic therapies.
Stem cell-loaded hydrogels represent a novel approach for sustained intraocular drug delivery and ocular surface repair.