Related Experiment Video
Updated: Mar 24, 2026

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids
Published on: May 3, 2024
Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell
Jie Liu1, Ziling Sun2, Yuqi Yuan1
1College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou, 215123, China.
Abstract:
Glycopeptide-based hydrogelators with well-defined molecular structures and varied contents of sugar moieties were prepared via in vitro peptide glycosylation reactions. With systematic glucose modification, these glycopeptide hydrogelators exhibited diverse self-assembling behaviors in water and formed supramolecular hydrogels with enhanced thermostability and biostability, in comparison with their peptide analogue. Moreover, because of high water content and similar structural morphology and composition to extracellular matrixes (ECM) in tissues, these self-assembled hydrogels also exhibited great potential to act as new biomimetic scaffolds for mammalian cell growth. Therefore, peptide glycosylation proved to be an effective means for peptide modification and generation of novel supramolecular hydrogelators/hydrogels with improved biophysical properties (e.g., high biostability, increased thermostability, and cell adhesion) which could promise potential applications in regenerative medicine.
More Related Videos
Related Concept Videos
Protein Glycosylation
Glycosylation occurs in...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Proteoglycans
Matrix Proteoglycans and Glycoproteins
Peptidoglycan Synthesis
Glycocalyx and its Functions

