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Updated: Mar 24, 2026
A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture
Published on: March 17, 2023
Photodynamic activity of thiophene-derived lysosome-specific dyes
Francesca Baldassarre1, Federica Foglietta2, Viviana Vergaro1
1University of Salento, Biological and Environmental Sciences Department, Via Monteroni, 73100 Lecce, Italy.
Abstract:
The photodynamic activity occurring through the lysosome photo-damage is effective in terms of triggered synergic effects which can avoid chemo-resistance pathways. The potential photodynamic activity of two fluorescent lysosome-specific probes was studied providing their interaction with human serum albumin, demonstrating their in vitro generation of singlet oxygen and investigating the resulted photo-toxic effect in human cancer cells.
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