Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.8K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Laparoscopic Management of Pediatric Noncommunicating Hydrocele: A Comparative Study of Hydrocelectomy Versus Aspiration.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same author

Selective Management of Inguinal Canal Fat During TAPP Repair: Distinguishing True Lipoma from Preperitoneal Fat.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026
Same author

Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.

Microbiome·2026
Same author

Laparoscopic iliopubic tract repair for adolescent inguinal hernia: a large-scale cohort study of 433 cases demonstrating a safe, mesh-free technique.

Hernia : the journal of hernias and abdominal wall surgery·2026
Same author

Laparoscopic Orchiopexy for Pediatric Ectopic Testis.

Journal of laparoendoscopic & advanced surgical techniques. Part A·2026

Related Experiment Video

Updated: Mar 24, 2026

Single-Molecule Localization Microscopy of Membrane Proteins using Single-Antibody Labeling
07:51

Single-Molecule Localization Microscopy of Membrane Proteins using Single-Antibody Labeling

Published on: March 20, 2026

11

Tetraspanins: Spanning from solid tumors to hematologic malignancies.

Ying-Gui Yang1, Ita Novita Sari1, Mohammad Farid Zia1

  • 1Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan, Republic of Korea.

Experimental Hematology
|March 2, 2016
PubMed
Summary

Tetraspanins are membrane proteins implicated in cancer. This review focuses on tetraspanin 3 in myeloid leukemia, highlighting their role in tumorigenesis and potential for novel cancer therapies.

More Related Videos

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

1.5K
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

859

Related Experiment Videos

Last Updated: Mar 24, 2026

Single-Molecule Localization Microscopy of Membrane Proteins using Single-Antibody Labeling
07:51

Single-Molecule Localization Microscopy of Membrane Proteins using Single-Antibody Labeling

Published on: March 20, 2026

11
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

1.5K
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

859

Area of Science:

  • Molecular biology
  • Oncology
  • Immunology

Background:

  • Tetraspanins are integral membrane proteins with a conserved structure.
  • Their precise biological functions are still being elucidated.
  • Tetraspanin expression is linked to the malignancy of various human tumors.

Purpose of the Study:

  • To review the role of tetraspanins in cancer.
  • To specifically examine the involvement of tetraspanin 3 in myeloid leukemia.
  • To discuss the potential of tetraspanins as therapeutic targets in cancer treatment.

Main Methods:

  • Literature review of existing studies on tetraspanins in cancer.
  • Analysis of genetic mouse models of tetraspanins.
  • Focus on tetraspanin 3 in the context of myeloid leukemia.

Main Results:

  • Tetraspanins play significant roles in solid tumors and hematologic malignancies.
  • Genetic studies in mice confirm tetraspanin involvement in tumorigenesis.
  • Tetraspanin expression levels correlate with tumor malignancy.

Conclusions:

  • Tetraspanins are crucial in cancer development and progression.
  • Tetraspanin 3 is a key player in myeloid leukemia.
  • Understanding tetraspanin function offers avenues for developing new cancer therapies.