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Genistein attenuates oxidative damage in preeclamptic placental trophoblast
Padmini Ekambaram1, Chithra Balan1, Christina Joseph Mary Susai1
1a Department of Biochemistry , Bharathi Women's College, Affiliated to University of Madras , Chennai , Tamil Nadu , India.
Objective:
To evaluate the effect of genistein supplementation on the oxidative/nitrative stress and antioxidant capacity of normotensive and preeclamptic placental trophoblast.
Methods:
The stress status of placental trophoblast was assessed by measuring their respective markers before and after incubation with genistein.
Results:
A significant increase in stress along with decrease in antioxidant status was observed in preeclamptic placental trophoblast, whereas genistein incubation significantly alters oxidant-antioxidant status.
Conclusion:
The study revealed that genistein may play a significant role in controlling oxidative/nitrative stress during preeclampsia. Hence, genistein can be used as an effective dietary supplement for the treatment and management of preeclampsia.
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