[Clonidine versus a placebo trial in manic disorder]
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M C Hardy-Bayle1, Y Lecrubier, S Lancrenon
1Travail du Service du Pr D. Widlöcher, U 302, Hôpital de la Salpêtrière, Paris.
L'Encephale
|November 1, 1989
Abstract:
Clonidine efficacy was evaluated in 24 manic inpatients, hospitalised in a locked ward. This is a double blind and randomized study. The duration of the trial was 14 days, and the daily dose of clonidine was 0.225 mg/day during the first week, increased to 0.450 mg/day during the second week, in the case of incomplete improvement. There was a trend for a better efficacy of clonidine over placebo, but this did not reach significant, due to an important amelioration of many patients under placebo. The effects of the hospitalisation in a locked ward are discussed.