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[Changes in small airway function in rhinitis without asthma].

Junfeng Ji, Qiuping Wang, Yong Zhang

    Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
    |March 3, 2016
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    Summary
    This summary is machine-generated.

    Patients with allergic rhinitis (AR) and non-allergic rhinitis (NAR) show impaired small airway function compared to healthy individuals. Some rhinitis patients exhibit airway hyperresponsiveness (AHR), linked to these functional changes.

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    Area of Science:

    • Respiratory Medicine
    • Allergology
    • Pulmonology

    Background:

    • Rhinitis, a common condition, can affect respiratory health.
    • Small airway dysfunction is a key indicator of respiratory disease.
    • Understanding rhinitis's impact on small airways is crucial for diagnosis and management.

    Purpose of the Study:

    • To investigate small airway function in patients with rhinitis without asthma.
    • To compare small airway function between allergic rhinitis (AR), non-allergic rhinitis (NAR), and healthy controls.
    • To assess the prevalence of airway hyperresponsiveness (AHR) in rhinitis patients and its relation to small airway function.

    Main Methods:

    • Recruited 903 subjects: 377 with AR, 262 with NAR, and 264 healthy controls.
    • Conducted comprehensive assessments including medical history, nasal examination, skin prick tests, blood tests, and lung function tests.
    • Utilized bronchial challenge tests to evaluate airway hyperresponsiveness (AHR).

    Main Results:

    • Patients with AR and NAR demonstrated significantly lower small airway function indices (e.g., FEV1/FVC%, MEF25pred%, MMEFpred%) compared to controls.
    • No significant differences in FVCpred% and FEV1pred% were observed between rhinitis groups and controls.
    • AHR was present in 12.2% of AR patients and 6.1% of NAR patients, with lower small airway function noted in those with AHR.

    Conclusions:

    • Rhinitis is associated with significant changes in small airway function compared to healthy individuals.
    • A subset of rhinitis patients exhibits airway hyperresponsiveness (AHR).
    • AHR in rhinitis patients is linked to alterations in small airway function.