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Vitamin E and cardiovascular disease.

J Kleijnen¹, P Knipschild, G ter Riet

¹Department of Epidemiology/Health Care Research, University of Limburg, Maastricht, The Netherlands.

European Journal of Clinical Pharmacology

|January 1, 1989

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Vitamin E may improve symptoms of intermittent claudication and angina pectoris. Further randomized clinical trials are needed to confirm these potential benefits for cardiovascular disease.

Area of Science:

Cardiovascular Medicine
Nutritional Science
Pharmacology

Background:

Intermittent claudication and angina pectoris are common cardiovascular conditions.
Vitamin E is an antioxidant with potential cardiovascular benefits.
Previous studies on Vitamin E for these conditions have methodological limitations.

Purpose of the Study:

To review randomized clinical trials on Vitamin E for intermittent claudication and angina pectoris.
To discuss potential mechanisms of Vitamin E action in cardiovascular disease.
To assess the need for further research.

Main Methods:

Systematic review of randomized clinical trials.
Analysis of methodological quality of included studies.
Discussion of pharmacological evidence.

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Main Results:

Methodological shortcomings were identified in existing trials.
Evidence suggests potential benefits of Vitamin E, particularly for intermittent claudication.
Pharmacological actions support the rationale for Vitamin E use.

Conclusions:

Vitamin E may offer a positive effect on cardiovascular symptoms, especially intermittent claudication.
Further high-quality randomized clinical trials are warranted.
The review highlights the need for rigorous study designs.