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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
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Smart Contrast Agents for Magnetic Resonance Imaging
1Centre de Biophysique Moléculaire CNRS, UPR4301, Université d'Orléans Rue Charles Sadron, 45071 Orléans, France.
Chimia
|March 3, 2016
Summary
Molecular imaging uses magnetic resonance imaging (MRI) contrast agents to detect biomarkers. Responsive T(1) and paramagnetic chemical exchange saturation transfer (PARACEST) agents are designed for in vivo molecular detection.
Area of Science:
- Biomedical imaging
- Molecular biology
- Radiochemistry
Background:
- Molecular imaging visualizes bioactive molecules and biological parameters in vivo for molecular-level information.
- Magnetic resonance imaging (MRI) utilizes paramagnetic metal ion complexes to enhance image contrast.
- Contrast enhancement in MRI is achieved through T(1) agents or paramagnetic chemical exchange saturation transfer (PARACEST) agents.
Purpose of the Study:
- To review recent advancements in responsive T(1) and PARACEST MRI agents.
- To highlight strategies for designing molecular imaging agents that respond to biological parameters.
- To showcase applications in detecting biogenic metal ions, enzymatic activities, and neurotransmitter release.
Main Methods:
- Review of literature and group's research on responsive MRI agents.
- Design principles for T(1) and PARACEST agents.
- Application of these agents for detecting specific biomarkers.
Main Results:
- Responsive T(1) and PARACEST agents can be designed to detect various biomarkers.
- Examples include detection of calcium, zinc, enzymatic activities, and neurotransmitter release.
- These agents provide MRI-detectable responses to biological parameters.
Conclusions:
- Molecular imaging with responsive MRI agents enables earlier and personalized diagnosis.
- These agents aid in understanding physiological and pathological processes at a molecular level.
- General strategies exist for creating molecular imaging agents with MRI-detectable responses.
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