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Celiac crisis in children in Serbia

Nedeljko Radlovic1,2,3, Zoran Lekovic4,5, Vladimir Radlovic6

  • 1Faculty of Medicine, University of Belgrade, Dr Subotica 9, Belgrade, 11000, Serbia. n.radlovic@beotel.net.

Italian Journal of Pediatrics
|March 3, 2016
PubMed

Insights

Celiac crisis (CC) affects 1.63% of children with celiac disease (CD), primarily under two years old. Infections and malnutrition are key risk factors for this severe complication of undiagnosed CD.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
  • Celiac crisis (CC) is a rare but severe manifestation of CD in children.
  • Understanding CC prevalence and risk factors is crucial for early diagnosis and management.

Purpose of the Study:

  • To determine the incidence of celiac crisis in children diagnosed with classical celiac disease.
  • To identify potential risk factors and triggers associated with celiac crisis development.

Main Methods:

  • Retrospective analysis of 367 children diagnosed with classical CD between 1994 and 2015.
  • CD diagnosis adhered to revised ESPGHAN criteria.
  • CC diagnosis based on acute gastrointestinal symptoms, dehydration, metabolic derangements, and weight loss.

Main Results:

  • Celiac crisis occurred in 6 children (1.63%), predominantly within the first year of life.
  • Infections (rotavirus, Salmonella) precipitated CC in 4 cases.
  • Undiagnosed CD, malnutrition, and prolonged disease duration were contributing factors in the remaining cases.

Conclusions:

  • Celiac crisis remains a relevant complication in Serbian children, primarily affecting those under two years old.
  • CC often presents as a complication of previously unrecognized celiac disease.
  • Intestinal infections and severe malnutrition are significant precipitating factors for celiac crisis.
Abstract

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