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IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
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A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of
Lihua Lu1, Modi Wang1, Zhifeng Mao1
1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Scientific Reports
|March 3, 2016
Abstract:
A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.

