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Association between Gastroesophageal Reflux Disease and Appendicitis: A Population-Based Case-Control Study
Li-Ting Kao1,2, Ming-Chieh Tsai3,4, Herng-Ching Lin2,4
1Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.
Scientific Reports
|March 3, 2016
Summary
Gastroesophageal reflux disease (GERD) is linked to a higher risk of appendicitis. This study found individuals with appendicitis were twice as likely to have a history of GERD, indicating a significant association.
Area of Science:
- Gastroenterology
- Epidemiology
Background:
- Appendicitis and gastroesophageal reflux disease (GERD) are common conditions.
- Potential shared pathological mechanisms between appendicitis and GERD warrant investigation.
Purpose of the Study:
- To examine the association between GERD and appendicitis.
- Utilize a large population-based dataset to determine this relationship.
Main Methods:
- Retrospective cohort study using administrative claims data from Taiwan.
- Identified 7113 appendicitis cases and 28452 matched controls.
- Conditional logistic regression analysis was performed.
Main Results:
- GERD prevalence was significantly higher in appendicitis cases (5.05%) compared to controls (2.56%).
- The adjusted odds ratio (OR) for GERD in appendicitis patients was 2.05.
- Increased ORs for GERD were observed across all age groups (18-39, 40-59, ≥60 years).
Conclusions:
- Appendicitis patients demonstrate a significantly higher likelihood of having a prior GERD diagnosis.
- The association between GERD and appendicitis is consistent across different age demographics.
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