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Inflammatory arthritis in HIV positive patients: A practical guide
T Adizie1, R J Moots2,3, B Hodkinson4
1Rheumatology Department, Heart of England NHS Trust, Birmingham, UK. toch1@doctors.org.uk.
BMC Infectious Diseases
|March 3, 2016
Summary
Managing inflammatory arthritis in human immunodeficiency virus (HIV)-positive patients presents challenges. This review covers clinical characteristics and therapeutic options for HIV-associated articular syndromes.
Area of Science:
- Rheumatology
- Infectious Diseases
- Immunology
Background:
- Musculoskeletal manifestations are common in human immunodeficiency virus (HIV) infection.
- Associated articular syndromes include HIV-associated arthropathy, spondyloarthropathies (SPA), rheumatoid arthritis (RA), and painful articular syndrome.
Purpose of the Study:
- To review the clinical characteristics of inflammatory articular syndromes in HIV-infected individuals.
- To discuss current therapeutic options for these patients.
Main Methods:
- A comprehensive literature search of PubMed (1981-2015) was conducted.
- Keywords included HIV, rheumatic manifestations, arthritis, spondyloarthropathy, anti-TNF, and disease-modifying antirheumatic drugs.
- English language studies involving adult subjects were included.
Main Results:
- Management of inflammatory arthritis in HIV-positive individuals is challenging.
- Difficulties exist in assessing disease activity and understanding drug safety in this population.
Conclusions:
- This review synthesizes information on HIV-associated inflammatory articular syndromes.
- It provides insights into clinical features and treatment strategies for affected patients.
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