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Updated: Mar 24, 2026

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A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR)

A Sonato1, M Agostini2, G Ruffato3

  • 1CNR-IOM, Area Science Park, S.S. 14, km 163.5, 34149, Basovizza (TS), Italy.

Lab on a Chip
|March 3, 2016
PubMed
Summary

This study introduces a novel microfluidic biosensor combining surface acoustic wave (SAW) mixing with surface plasmon resonance (SPR) for enhanced molecule binding. The device significantly speeds up binding kinetics, offering a portable solution for diverse biosensing applications.

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Area of Science:

  • * Nanotechnology and Microfluidics
  • * Biosensing and Surface Chemistry
  • * Acoustic and Optical Physics

Background:

  • * Traditional biosensors face limitations in sensitivity and speed.
  • * Microfluidic devices offer miniaturization but often lack efficient mixing.
  • * Surface plasmon resonance (SPR) and surface acoustic wave (SAW) technologies have independent applications in sensing.

Purpose of the Study:

  • * To develop a novel microfluidic biosensor integrating SAW and SPR.
  • * To enhance molecule binding kinetics through SAW-induced chaotic advection.
  • * To demonstrate the device's utility for real-time kinetic monitoring.

Main Methods:

  • * Fabrication of a lab-on-a-chip device using lithium niobate.
  • * Integration of phase-interrogation grating-coupling SPR with SAW.
  • * Monitoring of thiol-polyethylene glycol and avidin/biotin binding kinetics.

Main Results:

  • * Achieved significant reduction in binding time: 82% for polyethylene and 24% for avidin.
  • * Demonstrated enhanced fluid mixing via SAW-generated chaotic advection.
  • * Validated the high sensitivity of grating-coupling SPR under azimuthal control.

Conclusions:

  • * The developed SAW-SPR microfluidic biochip is the first of its kind.
  • * The device significantly improves molecule binding kinetics on a portable platform.
  • * The proposed biochip is versatile for various biosensing applications.